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J. R. WILLIAMS, Jr., M.D.; ARTHUR GROLLMAN, M.D.; T. R. HARRISON, M.D.

Arch Intern Med. 1941;67(5):895-906.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The problem of the possible significance of renin in the production of hypertension is fundamentally important in determining possible approaches to the therapeusis of this disorder. The available evidence on this point is, however, conflicting. Thus, Harrison, Blalock, Mason and Williams¹ and Prinzmetal, Friedman and Abramson² observed that extracts of ischemic dog kidneys cause a greater rise in blood pressure than do those of normal kidneys. On the other hand, Pickering and Prinzmetal³ failed to observe an augmented pressor effect in extracts of ischemic rabbit kidneys, while Beckwith and Chanutin⁴ found that the pressor activity of the kidney remnants of rats with hypertension due to subtotal nephrectomy was less than that of normal kidneys from rats with normal blood pressure.

Several possible explanations for the divergent results obtained by previous workers suggest themselves: (1) differences in methods of preparation; (2) species differences of the animals (dog, . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN.; BALTIMORE; NASHVILLE, TENN.

From the Department of Medicine, Vanderbilt University School of Medicine, and the Department of Pharmacology and Experimental Therapeutics, the Johns Hopkins University.

Footnotes
This work was aided by grants from the Josiah Macy Jr. Foundation and from Mr. Joe Werthan.

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