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M. RACHMILEWITZ, M.D.

Arch Intern Med. 1941;67(6):1132-1143.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since the introduction of chemical analysis of blood in the investigation of renal disease and the use of tests of renal function, true uremia is considered as poisoning due to retention in the blood of urinary waste products. Almost every urinary constituent has been considered as the basic substance which causes the clinical symptoms displayed by patients with uremia. The attempt, however, to hold a single "uremia toxin" responsible for the clinical picture of uremia has failed. No single substance has been discovered the retention of which, as a result of renal insufficiency, produces uremia. The concept prevailing now (Volhard,¹ Fishberg² and Harrison and Mason³) has been clearly expressed by Fishberg: "Uremia is a complex autointoxication, the variegated clinical picture being the summation of the effects of retention of various urinary constituents." The most important substances which are considered as playing a role in the production of . . . [Full Text PDF of this Article]

Author Affiliations
With the Assistance of Miss E. Nussbaum JERUSALEM, PALESTINE

From the Department of Experimental Pathology (Cancer Laboratories), the Hebrew University and Medical Department B of the Rothschild Hadassah University Hospital.

Footnotes
Aided by a grant from the Los Angeles Fund through Dr. J. Pollia.

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