This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

REVIEW OF CERTAIN RECENT CONTRIBUTIONS

EDWARD H. RYNEARSON, M.D.; ALICE G. HILDEBRAND, M.D.

Arch Intern Med. 1941;68(1):134-175.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

GLYCOGEN AND CARBOHYDRATE METABOLISM

In last year's review the importance of the work of Cori and his associates¹ on the synthesis of glycogen in vitro by the action of an enzyme called phosphorylase was pointed out. Phosphorylase, which is found in liver and muscle extracts and in yeast, acts on dextrose and phosphoric acid in the presence of adenylic acid, which acts as a coenzyme. Cori proceeded further in this investigation and in a recent paper² outlined the steps in the metabolism of glycogen as follows: 1. Glycogen plus phosphoric acid in the presence of the glycogen phosphorylase found in liver and other tissue yields dextrose-1-phosphate. This is a reversible reaction. 2. Dextrose-1-phosphate in the presence of phosphoglucomutase, an enzyme which is found in all tissue extracts, yields dextrose-6-phosphate. This reaction is irreversible. 3. Dextrose-6-phosphate in the presence of isomerase, an enzyme which is found in all tissue . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Medicine, the Mayo Foundation ROCHESTER, MINN.

From the Division of Medicine (Dr. Rynearson), the Mayo Clinic.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?