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REPORT OF TWO CASES

EDWARD B. MILLER, M.D.; WILLIAM DAMESHEK, M.D.

Arch Intern Med. 1941;68(3):375-394.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The possible relation between pernicious anemia and "primary," or "idiopathic," hypochromic anemia has been emphasized in a number of reports. The common denominator in these conditions may lie in a disturbance in the gastric secretion. Castle and his collaborators¹ demonstrated the importance of a defect in gastric secretion in the pathogenesis of pernicious anemia. Davies,² Dameshek,³ Hartfall and Witts⁴ and others found either complete achlorhydria or distinct hypoacidity in the great majority of their cases of "primary," or "idiopathic," hypochromic anemia. It has, furthermore, been noted that complete gastrectomy or a widespread malignant condition of the stomach is not infrequently followed by the development of either the "liver extract" deficiency or the iron deficiency type of anemia.⁵

The relation between pernicious anemia and "primary" hypochromic anemia was first suspected when it was noted that achlorhydria was often familial.⁶ It was occasionally reported that one or more members . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Joseph H. Pratt Diagnostic Hospital and the Blood Clinic, Boston Dispensary.

Footnotes
Aided by grants from the Charlton Fund, Tufts College Medical School, and the Milton Fund of Harvard University.

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