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I. QUANTITATIVE STUDIES OF THE VARIATIONS IN THE RATE OF COMBUSTION OF CARBOHYDRATE PRODUCED BY ALTERATIONS IN THE DIET

JEROME W. CONN, M.D.; ELIZABETH STERN CONN, M.D.

Arch Intern Med. 1941;68(5):876-892.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Soon after physicians had come to recognize the characteristic symptoms of insulin hypoglycemia, Harris,¹ in 1924, proposed the concept of endogenous hyperinsulinism. He had noted, in several patients, symptoms similar to those observed after an overdose of insulin and had demonstrated the presence of abnormally low levels of the blood sugar for the duration of such symptoms. He had shown, further, that the symptoms could be relieved promptly by the oral administration of carbohydrate foods. In 1927 Wilder, with others,² in a classic report, presented indisputable evidence that neoplastic pancreatic islet tissue, by producing excessive amounts of substance having the physiologic properties of insulin, caused spontaneous hypoglycemia. It has since been demonstrated repeatedly³ that complete surgical removal of islet cell tumors results almost invariably in disappearance of the hypoglycemic state. Although almost 100 cases have now been reported in which pancreatic islet cell tumors, associated with clinical . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

From the Department of Internal Medicine, University of Michigan Medical School.

Footnotes
The expense of these studies was defrayed in part by a grant from the Horace H. Rackham and Mary A. Rackham Foundation.

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