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METABOLISM IN ORGANIC HYPERINSULINISMII. EFFECTS OF EPINEPHRINE ON GLYCEMIC LEVEL AND ON COMBUSTION OF CARBOHYDRATE
JEROME W. CONN, M.D.;
ELIZABETH STERN CONN, M.D.
Arch Intern Med. 1941;68(6):1105-1114.
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The effects of the administration of epinephrine on the metabolism of carbohydrate in normal human subjects and in normal animals have been studied extensively.1 With regard to the specific effect of epinephrine on total combustion of carbohydrate in the normal organism there is great disagreement. Colwell and Bright,1f using normal intact animals, showed that the slow, continuous infusion of a solution of epinephrine hydrochloride resulted in complete suppression of carbohydrate combustion, as indicated by the respiratory gaseous exchange, despite the fact that a continuous, excessive supply of dextrose was being simultaneously infused. They found further that when the nonprotein respiratory quotient reached the level interpreted as indicating exclusive combustion of fat, the recovery of urinary dextrose equaled the intravenous supply and that the cessation of infusion of a solution of epinephrine hydrochloride resulted in diminishing glycosuria, a rising respiratory quotient, diminishing urinary excretion of nitrogen and deposition of
. . . [Full Text PDF of this Article]
Author Affiliations
ANN ARBOR, MICH.
From the Department of Internal Medicine, University of Michigan Medical School.
Footnotes
The expense of these studies was defrayed in part by a grant from the Horace H. Rackham and Mary A. Rackham Foundation.
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