This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A. CANTAROW, M.D.; C. L. CUBBERLEY, Jr., M.D.; A. E. RAKOFF, M.D.

Arch Intern Med. 1942;69(3):456-459.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is commonly believed that sulfanilamide compounds diffuse readily from the blood into the tissue fluids and that an equilibrium between these two mediums is established rapidly. In commenting on this phenomenon, the majority of authors refer to the observations of Marshall and Long,¹ which led to the conclusion that the distribution of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) between the blood and the tissues is "complete or nearly complete in five to ten minutes" after its administration intravenously. This conclusion was based on the observation that the most marked decrease in the concentration of sulfapyridine in the blood occurred during the first five to ten minutes, with only a relatively slight drop during the next hour. Review of their data, however, reveals that few determinations were made five and ten minutes after the compound was administered and that in the majority of instances sulfapyridine was present in the blood (and presumably in . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Departments of Medicine and Obstetrics, Jefferson Medical College, and the Laboratory of Biochemistry, Jefferson Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?