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FURTHER OBSERVATIONS

RAY D. WILLIAMS, M.D.; HAROLD L. MASON, Ph.D.; BENJAMIN F. SMITH, M.D.; RUSSELL M. WILDER, M.D., Ph.D.

Arch Intern Med. 1942;69(5):721-738.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In earlier studies¹ a group of 4 subjects was maintained for 147 days and another group of 4 subjects for 88 days on a diet containing not more than 0.15 mg. of thiamine (0.07 mg. for each 1,000 calories of the standard diet). This provision of thiamine represented a restriction to little more than a sixth of the amount of thiamine considered at the time to be the minimal daily requirement.²

The disease induced by this severe, isolated restriction of thiamine minutely resembled in the early stages the disturbance which commonly is known as "anxiety neurosis," but which the discriminating psychiatrist designates as "neurasthenia." At the end of the period of deprivation of thiamine the clinical picture was that of anorexia nervosa. Inactivity, apathy, serious derangement of metabolic processes, loss of weight and, finally, prostration, were observed in all subjects. None of these signs and symptoms developed in . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Division of Medicine, Mayo Clinic (Dr. Williams and Dr. Wilder), the Division of Biochemistry (Dr. Mason) and the Department of Neurology and Psychiatry, the Mayo Foundation (Dr. Smith).

Footnotes
Presented in abstract to the American Institute of Nutrition, Chicago, April 16, 1941. A preliminary report of this study has been published (Williams, R. D., and Mason, H. L.: Further Observations on Induced Thiamine [Vitamin B1] Deficiency and Thiamine Requirement of Man: Preliminary Report, Proc. Staff Meet., Mayo Clin. 16:433-438 [July 9] 1941).

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