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WITH A METHOD OF ADMINISTRATION TO MAINTAIN UNIFORM BLOOD LEVELS FOR THE TREATMENT OF SERIOUS STAPHYLOCOCCIC INFECTIONS AND SUBACUTE BACTERIAL ENDOCARDITIS

EDWIN E. OSGOOD, M.D.

Arch Intern Med. 1942;69(5):746-765.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Neoarsphenamine has been widely used in the therapy of syphilis since the synthesis of the drug by Ehrlich, but it has received relatively little attention as a chemotherapeutic agent against other bacterial infections. Reports by E. LeCocq¹ and J. LeCocq² of its effectiveness in the treatment of serious staphylococcic infections led to experimental³ and clinical⁴ confirmation of its effectiveness against staphylococci. This paper summarizes results of studies in progress, details of which were presented in an exhibit at the 1941 session of the American Medical Association and will appear in subsequent publications. It is hoped that this summary will stimulate further investigation of neoarsphenamine and related compounds as chemotherapeutic agents against bacterial infections.

In previous publications,³ by use of the marrow culture technic, which permits controlled quantitative studies of the effectiveness of chemotherapeutic agents against bacterial infections in the presence of living human cells, it . . . [Full Text PDF of this Article]

Author Affiliations
PORTLAND, ORE.

From the Department of Medicine and the Division of Experimental Medicine, University of Oregon Medical School.

Footnotes
Read before the Section on Pharmacology and Therapeutics at the Ninety-Second Annual Session of the American Medical Association, Cleveland, June 5, 1941.

This study was aided by grants from the Department of Clinical Research, Abbott Laboratories, Inc., Dr. L. B. Kingery and the Lola Norwood Diack Trust. The drugs used were supplied by the Abbott Laboratories, Inc., the Winthrop Chemical Co., Inc., Parke, Davis & Co., and Dr. J. G. M. Bullowa, New York.

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