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ALBERT J. LUBIN, M.D.

Arch Intern Med. 1942;69(5):836-855.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

On the basis of experimental paralyses produced in animals by Evans and Burr,¹ Einarson and Ringsted² and others, vitamin E and alpha tocopherol, an alcohol isolated from wheat germ oil having apparently all of the properties of the vitamin, have been rather widely advocated as therapeutic agents for a variety of diseases of the neuromuscular system, especially amyotrophic lateral sclerosis and progressive muscular dystrophy. The favorable clinical reports of Bicknell³ and Wechsler⁴ have been followed by those of Stone,⁵ Vilter, Aring and Spies,⁶ and Rosenberger⁷ and by a considerable body of literature distributed by various pharmaceutic companies and, indeed, by the lay press. However, the reports of others⁸ make it clear that the efficacy of the therapy is far from proved.

This report covers a group of 35 patients treated with large doses of synthetic alpha tocopherol, beginning May 1940. The purpose of the study was to . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Department of Medicine (Division of Neuropsychiatry), Stanford University School of Medicine.

Footnotes
The synthetic alpha tocopherol was supplied by Merck & Co., Inc. and by Hoffmann-Laroche, Inc. through the cooperation of Dr. Herbert M. Evans, of the University of California.

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