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ARTHUR M. MASTER, M.D.; JENNY STRICKER, M.D.; ARTHUR GRISHMAN, M.D.; SIMON DACK, M.D.

Arch Intern Med. 1942;69(6):1010-1018.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The purpose of this study is to demonstrate the beneficial effect of undernutrition and reduction in weight on the heart and circulation. The influence of a low calory diet on pulse rate, blood pressure, oxygen consumption, arteriovenous oxygen difference and cardiac output was determined over a long period in normal overweight subjects.

In obesity the heart functions under two handicaps. In the first place, the increased surface area results in an absolute rise in total body metabolism and oxygen consumption, which augments the work of the heart. Secondly, the elevated diaphragm limits the respiratory movements and compresses the lungs, causing a reduction in vital capacity. Both of these factors place a burden on the heart and explain the tendency of obese persons to fatigue and to dyspnea on mild effort, indicative of diminished exercise tolerance.

In studies on dietary restriction in subjects of normal weight Benedict and his co-workers¹ . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Cardiographic Laboratory, Mount Sinai Hospital.

Footnotes
Fellow of the Dazian Foundation for Medical Research.

This investigation was aided by a grant from the American Medical Association.

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