This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ARTHUR R. COLWELL, M.D.; JOSEPH LEWIS IZZO, M.D.; WALTER A. STRYKER, Ph.D., M.D.

Arch Intern Med. 1942;69(6):931-951.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

From the standpoint of clinical usefulness in cases of severe diabetes neither of the two standard insulins, soluble insulin and protamine zinc insulin, is ideal for routine day by day use. Because it is in solution, ordinary insulin is absorbed rapidly and within a short time exerts a strong effect which fades quickly. Hence it must be given frequently, and in excess it tends to cause violent hypoglycemic symptoms. With soluble insulin alone it is impossible to control severe diabetes in many cases unless multiple daily injections are given, including one during the normal sleeping hours. The same is true of solution of zinc insulin crystals, or crystalline insulin, the action of which is practically identical with that of ordinary insulin.¹ Protamine zinc insulin eliminates some of these disadvantages because it releases insulin slowly. Its effects are slow in onset, weak until reenforced by repeated overlapping doses but slow . . . [Full Text PDF of this Article]

Author Affiliations
EVANSTON, ILL.

From the Department of Medicine, Northwestern University Medical School, and Evanston Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?