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NAHUM J. WINER, M.D.

Arch Intern Med. 1942;70(1):61-87.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Diabetes insipidus and the mechanism of its underlying disturbance have long been a source of interest to investigators. During the last two to three decades a considerable literature has developed along various lines of approach, such as the central nervous system, the endocrine system, the body metabolism and the kidney. It is the last of these that is of particular interest, with specific regard to renal hemodynamics, water exchange and the relation of both to the pituitary.

REVIEW OF LITERATURE

These three aforementioned aspects of renal function, both in physiologically normal persons and in patients with diabetes insipidus, can be resolved into several fundamental questions: 1. To what extent is the amount of urine excreted a function of (a) renal blood flow or (b) glomerular filtration? 2. (a) What is the relation of the pituitary to urine output as regards both diuresis and antidiuresis? (b) Is the mechanism of its . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Medical Clinic of the Peter Bent Brigham Hospital and the Department of Medicine, Harvard Medical School.

Footnotes
Alice G. Sachs Fellow in Medicine.

This study was aided by the fund for study of renal vascular disease.

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