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METABOLIC FACTORS AND ELECTROENCEPHALOGRAPHIC CORRELATIONS

GEORGE L. ENGEL, M.D.; SYDNEY G. MARGOLIN, M.D.

Arch Intern Med. 1942;70(2):236-259.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Clinical manifestations of disease are in the final analysis the result of altered physiologic or biochemical relations. This is true whether one observes the direct evidence of abnormal function or the compensatory reactions invoked to counteract abnormal forces. The central nervous system is no exception to this principle. And this is no less true whether one deals with disease directly involving the central nervous system or with the effects on it of disease having its origin elsewhere. This report is concerned with secondary effects. Neuropsychiatric complications of underlying disease may vary widely from mild aberrations of normal mood and behavior to sweeping disturbances that dominate the entire clinical picture and may obscure the disease itself.

The basis for these reactions depends primarily on the fundamental nature of brain metabolism. The central nervous system has the most exacting metabolic requirements in the body. Unlike other tissues, it is primarily aerobic in . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI; NEW YORK

From the Neurological Service of Dr. I. S. Wechsler and the Medical Service of Dr. E. Moschcowitz, Mount Sinai Hospital, New York.

Footnotes
Parts of this material were presented at a meeting of the New York Neurological Society, Dec. 3, 1940 (Margolin, S. G.; Strauss, H., and Engel, G. L.: Electroencephalographic Changes Associated with Hypersensitivity of the Carotid Sinus, Arch. Neurol. & Psychiat. 45:889 [May] 1941. Engel, G. L., and Margolin, S. G.: Clinical Correlation of the Electroencephalogram with Carbohydrate Metabolism, ibid. 45:890 [May] 1941) and at a meeting of the New York Academy of Medicine, Section of Neurology and Psychiatry, and the New York Neurological Society, Jan. 7, 1941 (Engel, G. L., and Margolin, S. G.: Neuropsychiatric Disturbances in Addison's Disease and the Role of Impaired Carbohydrate Metabolism in Production of Abnormal Cerebral Function, ibid. 45: 881 [May] 1941).