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HERBERT SILVETTE, Ph.D.

Arch Intern Med. 1942;70(4):567-584.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Extensive studies of the effects of barbiturates on renal function are few. Epstein investigated the influence of certain barbiturates on diuresis in rabbits caused by thyroxin¹ and by sodium chloride.² In 1930 Ogden³ described the action of amytal in inhibiting water diuresis in dogs during anesthesia, an observation which has been confirmed in many teaching laboratories. Walton⁴ and Gouax, Cordill and Eaton⁵ did not observe any significant effect of sodium amytal on the twenty-four hour output of urine, though this is rather misleading, since suppression of renal activity during a short period of anesthesia was compensated for by subsequent diuresis. It is, moreover, generally recognized that in clinical cases of severe sodium amytal intoxication secretion of urine is apt to be scanty.⁶ In the case of pentothal sodium, it has been reported that when the drug was used as an anesthetic in urologic practice, no change in . . . [Full Text PDF of this Article]

Author Affiliations
CHARLOTTESVILLE, VA.

From the Pharmacological Laboratory of the University of Virginia.

Footnotes
This investigation has been made with the assistance of a grant from the Committee on Therapeutic Research, Council on Pharmacy and Chemistry, American Medical Association.