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CLINICAL STUDIES

SAMUEL S. ALTSHULER, M.D.; HILDA M. HENSEL, M.D.; PAUL HECHT, M.D.; RICHARD PURSLEY, B.S.

Arch Intern Med. 1942;70(5):749-762.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In an earlier paper¹ it was shown that substitution of a mixture of essential amino acids for food protein is possible. A hydrolysate of casein reenforced by the addition of tryptophan was given subcutaneously or intravenously to normal persons and to patients after operation. Five of the 7 normal subjects stayed in nitrogen balance throughout the experiment. In the surgically treated subjects the injections helped to maintain nitrogen equilibrium.

Naturally, the question arose whether such injection of amino acids would be efficacious in the treatment of patients suffering from various disorders. In pursuit of this problem the following study was undertaken.

MATERIAL AND METHOD

Nitrogen balance studies were made on 19 subjects observed over periods of two to thirteen weeks. There were 9 patients with malignant growths, 3 with hyperthyroidism, 1 with myxedema, 2 with empyema, 2 with chronic glomerulonephritis, 1 with cirrhosis of the liver and 1 with . . . [Full Text PDF of this Article]

Author Affiliations
Attending Physician, William J. Seymour Hospital, Eloise, Mich.; Instructor in Clinical Medicine, Wayne University College of Medicine, Detroit; Chemist, Department of Internal Medicine, William J. Seymour Hospital, Eloise, Mich. ELOISE, MICH.

Footnotes
Research Fellow, Department of Internal Medicine, William J. Seymour Hospital.

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