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ROBERT C. BATTERMAN, M.D.

Arch Intern Med. 1943;71(3):345-356.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since March 1941 I have had the opportunity to investigate a new synthetic analgesic drug, demerol,¹ for the treatment of pain due to a variety of medical and surgical conditions. A year's experience has definitely indicated its value as an analgesic agent, and it was therefore deemed advisable to report on its effectiveness, potency and safety. In addition, its pharmacologic action in man relative to a comparison with morphine will be considered briefly.

Eisleb and Schaumann² introduced the drug in 1939 in an effort to obtain a synthetic substitute for atropine. However, it was soon noted on pharmacologic grounds that in addition to a slight atropine-like action on all smooth muscle, the drug possessed the unexpected effect of a morphine-like response on the central nervous system. Extensive pharmacologic and toxicologic studies have since been reported by Duguid and Heathcote³; Schaumann⁴; Gruber, Hart and Gruber,⁵ and . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Therapeutics, New York University College of Medicine, and the Third (New York University) Division of Bellevue Hospital.

Footnotes
This paper was presented in part at a meeting of the American Society for Pharmacology and Experimental Therapeutics, Boston, April 1, 1942, and at a meeting of the American Therapeutic Society, Atlantic City, N. J., June 6, 1942.

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