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INCIDENCE AND CAUSES OF HYPERPROTEINEMIAA STUDY OF 4,390 CASES
LEONARD CARDON, M.D.;
DONALD H. ATLAS, M.D., Ph.D.
Arch Intern Med. 1943;71(3):377-390.
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We had observed 2 cases of relatively common diseases associated with hyperproteinemia (a case of subacute bacterial endocarditis and a case of cirrhosis and primary carcinoma of the liver).1 The simultaneous presence of 2 patients with the supposedly rare condition of hyperproteinemia, lying side by side, in a small (200 bed) semiprivate hospital prompted a study of the incidence and the causes of this condition in our climate and locality. This communication presents the results of a clinical-experimental investigation of this subject in a larger series of patients than has hitherto been reported.
LITERATURE
Jeghers and Selesnick,2 summarizing the determinations of total plasma protein made by the clinical laboratories of the Boston City Hospital, reported that the incidence of total protein over 8 Gm. per hundred cubic centimeters was 0.2 per cent of 557 determinations in 1934, 1.19 per cent of 526 determinations in 1935 and 2.4 per
. . . [Full Text PDF of this Article]
Author Affiliations
Attending Physician, Cook County Hospital, and Associate Attending Physician, Mount Sinai Hospital; Associate Attending Physician, Cook County Hospital Assisted by Matthew J. Brunner, M.D., Edward Aron, M.D., and S. Lloyd Teitelman, M.D. CHICAGO
From the department of medicine of the Northwestern University Medical School, the Cook County Hospital, the Robert B. Preble Memorial Laboratory and the Mount Sinai Hospital.
Footnotes
Formerly Josiah Macy Jr. Fellow in Medicine.
This investigation was aided by a grant from the Josiah Macy Jr. Research Foundation.
Chick embryo antigen (Lygranum) for the Frei test was furnished by E. R. Squibb & Sons Biological Laboratories.
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