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JOSEPH B. KIRSNER, M.D., Ph.D.; WALTER LINCOLN PALMER, M.D., Ph.D.

Arch Intern Med. 1943;71(3):415-421.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Alkalosis can result from administration of soluble alkali¹ or from deprivation of chloride² or from both. It has been shown³ also that the alkalosis observed during "Sippy" treatment with the administration of calcium carbonate is almost invariably associated with loss of gastric chloride and that in all probability the disturbance in the acid-base balance observed under these conditions is to be attributed to the loss of chloride rather than to calcium carbonate. If this thesis is correct, it should be possible to prevent the development of alkalosis by the administration of sodium chloride coincident with the administration of alkali. A study, therefore, was undertaken to determine the effect of the simultaneous administration of sodium chloride and calcium carbonate on the acid-base balance of a series of patients with peptic ulcer.

METHOD

Sodium chloride and calcium carbonate were given concurrently to 150 patients with peptic ulcer. Eight patients . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Frank Billings Medical Clinic, Department of Medicine, University of Chicago.

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