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ISOLATION AND IDENTIFICATION OF URINARY COPROPORPHYRIN ISOMERS

SAMUEL NESBITT, M.D.

Arch Intern Med. 1943;71(4):483-488.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Protoporphyrin III constitutes the prosthetic group of certain vital substances, notably hemoglobin.¹ Only porphyrins of isomeric series I and III occur naturally in plants and animals, and Fischer² pointed, out that it is inconceivable for porphyrins of types I and III to be transformed one to the other in any biologic process, that they must be formed individually in the physiologic synthesis. Porphyrin arises in the body during synthesis of hemoglobin rather than during its destruction, as had been supposed formerly, a small proportion of isomeric series I arising as a by-product of the main synthesis of isomeric series III intended for utilization in the manufacture of hemoglobin.³ The porphyrin of isomeric series I is not utilized and is excreted as coproporphyrin I, and any porphyrin of isomeric series III which has been synthesized in greater amounts than are necessary to meet the immediate requirements, or which . . . [Full Text PDF of this Article]

Author Affiliations
Associate Physician, New Haven Hospital; Instructor in Medicine, Yale University School of Medicine NEW HAVEN, CONN.

Footnotes
Abstract of portion of thesis submitted to the faculty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Medicine.

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