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PATHOLOGIC REPORT WITH UNUSUAL FINDINGS

A. M. RABINER, M.D.; CAPTAIN I. S. FREIMAN; N. APTER, M.D.

Arch Intern Med. 1943;71(6):836-843.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although mapharsen has been widely adopted in the treatment of syphilis since 1934, reports of fatalities from toxic effects following its use are few. In 1933 Cole and others¹ reported the first case of death attributed to mapharsen; acute nephrosis was the primary cause of death. Two years later Simon and Iglauer² reported a case in which a patient had died of anuria after five injections of mapharsen. Shortly afterward Rein and Wise³ added 2 more cases with fatal outcome. In 1 of these aplastic anemia had developed; in the other granulocytopenia. In 1941 Kirkham and Perlmutter⁴ reported a case in which death was due to aplastic anemia following twenty injections of mapharsen.

The first report of mapharsen therapy followed by involvement of the central nervous system appeared in 1939 from India. Rajam and Rao⁵ described a case in which hemorrhagic encephalitis followed the use . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN; MEDICAL CORPS, ARMY OF THE UNITED STATES; BROOKLYN

From the Neurologic Service and the Neuropathology Laboratory (Department of Pathology, Dr. William W. Hala, director), Kings County Hospital.

Footnotes
Presented at a meeting of the Brooklyn Neurological Society, Nov. 25, 1941.

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