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CARL G. MORLOCK, M.D.; BYRON E. HALL, M.D.

Arch Intern Med. 1943;72(1):69-77.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The hemorrhagic phenomena, so often a complication of hepatic disease, has long presented a serious medical problem, particularly when the disease is severe and of long duration. The isolation of vitamin K and its application to control of the hemorrhagic tendency in hepatic disease created the impetus for study which has increased appreciation of the role of the liver in the synthesis of factors necessary for normal coagulation of blood. For many years thrombin has been known to play a definite part in coagulation of blood, and its precursor, prothrombin, has been shown to be a product of hepatic metabolism. It now is known that a normally functioning liver is one factor necessary for the maintenance of a normal level of prothrombin in the plasma.¹

Experimentally and clinically, it has been demonstrated that in certain diseases of the liver, a diminished level of prothrombin in the blood often is . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Division of Medicine, the Mayo Clinic.

Footnotes
Read at the First Annual Meeting of the American Federation for Clinical Research, Minneapolis, April 20, 1942.

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