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IMMUNOLOGIC STUDIES

CALDERON HOWE, M.D.

Arch Intern Med. 1943;72(2):147-167.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Carrión's disease is the name applied to the clinical disease entity caused by infection with Bartonella bacilliformis. The term includes both the severe anemic stage of the disease, Oroya fever, and the less severe eruptive stage, verruga peruana. In the regions where the disease is prevalent the term la verruga is used to indicate any form it may assume.

Many aspects of Carrión's disease in its various phases remain to be explained. Noteworthy among these is the immunologic sequence occurring in a human being during the course of infection. That a tangible immunologic response in the form of agglutinins does occur in some instances has already been demonstrated.¹ It has been the primary purpose of the present investigation further to define the limits of this immunologic response in relation to the course of the disease and to attempt to ascertain what part, if any, the presence of specific agglutinins . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Comparative Pathology and Tropical Medicine, Harvard Medical School, Boston, and the National Institute of Hygiene and Public Health, Lima, Peru.

Footnotes
This investigation was financed in part from the Repayments Fund of the Department of Comparative Pathology and Tropical Medicine, Harvard Medical School.

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