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OBSERVATIONS ON TRAINED AND UNTRAINED NORMAL SUBJECTS AND ON PATIENTS WITH HEART DISEASE AND WITH HYPERTENSION

ZALE A. YANOF, M.D.

Arch Intern Med. 1943;72(2):239-244.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

An increase of lactic acid in the blood and tissues following exercise is one of the classic observations in physiology. Since this discovery an extensive literature has accumulated on changes in lactic acid as related to work, training and fatigue. More recently Dill and his group¹ have suggested that it be employed as an index of cardiovascular fitness. However, it is now the considered opinion of most biochemists² that pyruvic acid, and not lactic acid, is the core of the carbohydrate metabolism of tissues. In the breakdown of dextrose by the tissues all reactions appear to revolve around pyruvic acid as the pivotal point. Further interest has been attached to pyruvic acid because of Peters'³ discovery that the presence of vitamin B₁ is necessary for its oxidation. This displacement of lactic acid in the scheme of the carbohydrate metabolism of tissues by pyruvic acid led to . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine of the University of Chicago.

Footnotes
This investigation was aided by a fellowship grant from the Jessie Horton Koessler Fund of the Institute of Medicine, Chicago, and by a grant from the Douglas Smith Fund of the University of Chicago.

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