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NATHAN H. SHACKMAN, M.D.; JESSE G. M. BULLOWA, M.D.

Arch Intern Med. 1943;72(3):329-345.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sulfadiazine (2-[paraaminobenzenesulfonamido]-pyrimidine), the pyrimidine analog of sulfapyridine, has been shown by Feinstone and his associates¹ in their experiments with mice to be less toxic than either sulfapyridine or sulfathiazole. They found the drug to be readily absorbed into the blood and rapidly excreted in the urine. Higher concentrations were obtained with sulfadiazine than with equivalent doses of sulfapyridine or sulfathiazole. Long and his co-workers² reported that sulfadiazine was less effective at equivalent concentrations than sulfathiazole in the treatment of experimental pneumococcic infections in mice. Osgood and Bullowa,³ using tissue cultures, found sulfadiazine to be only one-quarter as effective against pneumococci as sulfapyridine and sulfathiazole in equivalent concentrations.

Studies on the action of sulfadiazine in human beings have been reported by various investigators.⁴ With an associate we⁵ have previously reported on the pharmacodynamics of the drug in man. It is well absorbed from the gastrointestinal tract. . . . [Full Text PDF of this Article]

Author Affiliations
Clinical Professor of Medicine, New York University College of Medicine, and Visiting Physician, Harlem Hospital and Willard Parker Hospital NEW YORK

From the Medical Service, Harlem Hospital, Department of Hospitals, New York city and the Littauer Pneumonia Research Fund of New York University College of Medicine These studies received additional support from the Metropolitan Life Insurance Company an from Mr. Bernard M. Baruch, Mr. Bernard M. Baruch Jr., Miss Belle N. Baruch and Mrs H. Robert Samstag.

Footnotes
Littauer Fellow in Pneumonia Research, Harlem Hospital.

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