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REPORT OF A CASE

DANIEL STATS, M.D.; JESSE G. M. BULLOWA, M.D.

Arch Intern Med. 1943;72(4):506-517.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The antigen-antibody reaction between human erythrocytes and serum in which hemagglutination is observed only at low temperatures (below 20 C.) has attracted the attention of immunologists¹ and clinicians² for many years. Unusual serologic features of this reaction, its association with so many diverse pathologic states (Raynaud's syndrome, acute and chronic acquired hemolytic anemias, trypanosomiasis, acute bacterial infections, cirrhosis of the liver, leukemia, pernicious anemia, lymphoblastomas and bland venous thrombosis^2a) and its presence in low titer in at least 95 per cent of normal persons³ have been recorded. There is only 1 report⁴ of the occurrence of gangrene of the extremities due to the action of a cold hemagglutinin. In the case we are reporting gangrene was much more extensive.

In the data that follow the essential characteristics of the phenomenon are presented. The differences between cold hemagglutination, panagglutination and pseudoagglutination (rouleau formation) will not be . . . [Full Text PDF of this Article]

Author Affiliations
Clinical Professor of Medicine NEW YORK

From the Medical Service of Harlem Hospital, City of New York Department of Hospitals, Dr. Oswald La Rotonda, director, and the Littauer Pneumonia Research Fund of New York University College of Medicine, Dr. Jesse G. M. Bullowa in charge.

Footnotes
These studies received additional support from the Metropolitan Life Insurance Company and from Mr. Bernard M. Baruch, Mr. Bernard M. Baruch Jr., Miss Belle N. Baruch and Mrs. H. Robert Samstag.

Dr. Stats was a Littauer Fellow in Pneumonia Research, Harlem Hospital. Dr. Bullowa is clinical professor of medicine, New York University College of Medicine, and visiting physician, Harlem Hospital and Willard Parker Hospital.

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