This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A COMPARATIVE STUDY

EDWIN E. OSGOOD, M.D.; JESSE G. M. BULLOWA, M.D.

Arch Intern Med. 1944;73(1):13-17.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In previous publications it has been shown that sulfanilamide is more effective against pneumococci in bone marrow cultures than antiserum is, that sulfanilamide plus antiserum is much more effective than either alone,¹ that sulfapyridine alone is much more effective than sulfanilamide plus antiserum and that sulfapyridine plus antiserum is definitely more effective than sulfapyridine alone.² Sulfathiazole has been shown to be much more effective against staphylococcic infections than sulfapyridine.³ The relative effectiveness of several sulfonamide drugs against pneumococci is presented in the present study.

The marrow culture method has proved to be effective for controlled, quantitative measurement of the action of therapeutic agents on bacteria in the presence of living human cells.⁴

EXPERIMENTAL STUDY

About 50 cc. of a culture which contained about 100,000,000 living human nucleated marrow cells in a medium which consisted of 35 per cent human cord serum obtained from the fetal side . . . [Full Text PDF of this Article]

Author Affiliations
Associate Professor of Medicine and Head of the Division of Experimental Medicine, University of Oregon Medical School PORTLAND, ORE.; Clinical Professor of Medicine, New York University College of Medicine; Visiting Physician, Harlem Hospital and Willard Parker Hospital NEW YORK With the Technical Assistance of INEZ E. BROWNLEE PORTLAND, ORE.

From the Medical Service of Harlem Hospital and the Department of Hospitals of the City of New York, Oswald LaRotunda, Director; from the Department of Medicine and the Division of Experimental Medicine, University of Oregon Medical School, and from the Littauer Pneumonia Research Fund of New York University College of Medicine.

Footnotes
Dr. Bullowa wrote this paper from marrow culture data submitted to him by Dr. Osgood. Because of a protracted illness, followed by death on Nov. 9, 1943, he was unable to include the clinical data as planned.

These studies received financial support from the Dazian Fund, the Littauer Pneumonia Research Fund, the Metropolitan Life Insurance Company, Mr. Bernard M. Baruch, Mr. Bernard M. Baruch Jr., Miss Belle N. Baruch and Mrs. H. Robert Samstag.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?