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ABRAHAM RUDY, M.D.; CAPTAIN SAMUEL B. BEASER; ARNOLD M. SELIGMAN, M.D.

Arch Intern Med. 1944;73(1):23-28.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1936 Szent-Györgyi and his associates¹ isolated a crystalline substance from lemons which they called citrin. They^1a found that this substance corrected the increased capillary fragility in guinea pigs on a scorbutogenic diet and in human beings with certain pathologic conditions. They called it vitamin P. Subsequently, studies both on animals and on human beings were carried out by numerous investigators. It was shown that citrin, a flavanone glucoside, is composed of two fractions, hesperidin glucoside² (formula I shows the aglycone), which is insoluble in water and is stable, and eriodictyol glucoside (formula II shows the aglycone), which is water soluble and sensitive to oxidation. Eriodictyol is demethylated hesperidin and contains the unstable orthohydroquinone group. It has been reported^1b that the relative amounts of these substances in citrin vary with the ripening of the fruit used in its preparation and with the method of isolation. However, . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON; MEDICAL CORPS, ARMY OF THE UNITED STATES; BOSTON

From the Medical and Surgical Services of the Beth Israel Hospital.

Footnotes
Aided by a grant from the Charlton Research Fund, Tufts College Medical School.

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