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WITH PARTICULAR REFERENCE TO THE ROLE OF THE LIVER AND KIDNEYS

ROBERT H. WILLIAMS, M.D.; GROSVENOR W. BISSELL, M.D.

Arch Intern Med. 1944;73(3):203-211.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Banga, Ochoa and Peters¹ have shown that most of the biologic activity of thiamine is exerted only when the latter exists in the form of diphosphothiamine. All of the nucleated cells of the body have been thought to possess the power to convert thiamine to diphosphothiamine,² the liver³ and the kidney⁴ possessing this activity more than the other tissues. Furthermore, these organs have a greater capacity for the dephosphorylation of diphosphothiamine.⁵

These observations introduce an important query as to whether with severe disease of the liver or kidneys there is a disturbance in thiamine metabolism. Certain studies that have been made suggest that such may be the case. For example, Borson⁶ found that 3 patients with hepatic cirrhosis, excreted a distinctly larger percentage of a standard test dose of thiamine than did his normal subjects. He suggested that the damage of the liver might cause a decrease . . . [Full Text PDF of this Article]

Author Affiliations
With the Assistance of Jean B. Peters BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School.

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