This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

CHESTER M. JONES, M.D.; WILLIAM P. CHAPMAN, M.D.

Arch Intern Med. 1944;73(4):322-328.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A comparative study has been made of the analgesic effects on human beings of morphine sulfate and one of its derivatives, monoacetylmorphine.¹ Twenty-four normal males, ranging in age from 17 to 25 years, were used as test subjects in the experiments. Pain was produced by means of heat stimulation of the skin of the forehead by means of a modified Hardy-Wolff² cutaneous heat radiation apparatus. Two components of the pain experience were studied: first, the threshold of perception of pain, and, second, the threshold of reaction to pain. The accuracy of the method had been established previously by control observations on the variations in sensitivity to pain in 200 normal subjects.³ The measure of the threshold of pain perception was taken to be the lowest strength of stimulus necessary to cause a sharp prick or piercing jab following a sensation of diffuse, burning heat. The threshold of . . . [Full Text PDF of this Article]

Author Affiliations
With the Technical Assistance of Robert Desautels; Charles Royer, A.B.; Bertram Roth, B.S., AND William Drucker, B.S. BOSTON

From the Medical Service of the Massachusetts General Hospital, and the Department of Medicine, Harvard University.

Footnotes
The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the Massachusetts General Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?