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(COOLEY'S ANEMIA; MEDITERRANEAN ANEMIA)

WILLIAM N. VALENTINE, M.D.; JAMES V. NEEL, Ph.D.

Arch Intern Med. 1944;74(3):185-196.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cooley's anemia,¹ or thalassemia,² is a rare but well known disease. This fatal disorder is characterized by a chronic, progressive, hypochromic and microcytic type of anemia, peripheral erythroblastosis, increased number of target and oval red blood cells, decreased fragility of erythrocytes, splenomegaly, deposition of pigment in the viscera and changes in the bones. The condition was early noted to have a familial incidence and to be virtually restricted to the Mediterranean peoples. In 1937, Angelini (quoted from Wintrobe and associates³) observed that in some instances the erythrocytes of apparently healthy parents and of siblings of patients suffering from this anemia showed decreased fragility. Caminopetros⁴ independently confirmed this observation, finding that 22 of 30 parents tested showed reduced fragility. He also reported slight changes in the bones in some parents. A few years later, Wintrobe, Matthews, Pollack and Dobyns³ described the occurrence in several Italian families . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, N. Y.

From the Departments of Medicine and Pediatrics, The University of Rochester School of Medicine and Dentistry, and the Strong Memorial and Rochester Municipal Hospitals.

Footnotes
Drs. John S. Lawrence, William L. Bradford, G. H. Whipple, Curt Stern and Lawrence Young gave many helpful suggestions and valuable criticisms. Mrs. Priscilla Neel assisted in the preparation of figures.

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