This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A REVIEW OF THE RECENT LITERATURE

FRANK H. BETHELL, M.D.; CYRUS C. STURGIS, M.D.; OTTO TOD MALLERY, Jr., M.D.; R. WAYNE RUNDLES, Ph.D., M.D.

Arch Intern Med. 1944;74(3):197-233.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

GRANULOCYTOPENIA AND AGRANULOCYTOSIS

Leukemoid Reactions.

—One case of osteopetrosis and 17 cases of myelofibrosis are reported by N. Rosenthal and Erf,³⁵⁸ with a discussion of the clinical and hematologic features and differential diagnosis of these conditions. Osteopetrosis occurs most often in childhood and is commonly associated with congenital abnormalities, mental retardation and usually enlargement of the liver and spleen. There is a generalized condensation of bone. Anemia is progressive and is usually associated with thrombopenia and leukopenia. Often immature cells of the myeloid series are seen in the peripheral blood. Myelofibrosis was first described by Hueck in 1879; since then approximately 75 cases have been reported. The diagnosis of the condition is generally made at autopsy. The clinical features include weakness, dyspnea, refractory anemia, splenomegaly, periostitis and pains in the bones. Myelofibrosis is observed equally often in the two sexes and has no predilection for . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?