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G. E. GUSTAFSON, Ph.D.; S. KOLETSKY, M.D.; A. H. FREE, Ph.D.

Arch Intern Med. 1944;74(6):416-423.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Certain substances have been shown to protect the kidneys from injury by heavy metals. Protection from poisoning by uranyl nitrate has been obtained by sodium carbonate,¹ sodium bicarbonate² and sodium citrate,³ and from mercuric chloride, by hemoglobin⁴ and testosterone.⁵ This study deals with the protective action of sodium citrate in dogs receiving an otherwise lethal dose of uranyl nitrate.

METHODS

Twenty female dogs, weighing between 7.7 and 20 Kg. and appearing in good health, were used as experimental animals. Those selected were neither extremely young nor senile. The diet was a commercial preparation of dog biscuits. There was no restric- tion of intake of water. Intravenously administered sodium pentobarbital was used as the anesthetic in obtaining biopsy specimens.

The uranyl nitrate was given intravenously in every instance. Sodium citrate was given by the oral or intravenous route prior to and after the injection of uranyl . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Biochemistry and the Institute of Pathology, School of Medicine, Western Reserve University.

Footnotes
Drs. William Abbott and Maynard Pride, Department of Surgery, Western Reserve University, assisted us in obtaining the biopsy specimens from the kidneys.

The data presented in this paper are taken from the dissertation submitted by G. E. Gustafson to the Graduate School of Western Reserve University, June 1943, in partial fulfilment of the requirements for the degree of Doctor of Philosophy.