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ROBERT H. DREISBACH, M.D.; WALTON VAN WINKLE, Jr., M.D.; P. J. HANZLIK, M.D.

Arch Intern Med. 1944;74(6):424-427.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Ever since the experimental demonstration by Abelous and Bardier¹ in 1909 that urine contains a "hypotensive" substance, periodically there have appeared favorable clinical reports of therapeutic usefulness of this or that tissue extract in treatment of hypertensive and myospastic states. The clinical usage has been practically limited to insulin-free pancreatic extracts which are also free from histamine and choline, the products most commonly used being depropanex and padutin. These and other similar extracts are not accepted by the Council on Pharmacy and Chemistry of the American Medical Association because of lack of convincing evidence of therapeutic value despite their experimental effectiveness on the circulation.² The value of depropanex and padutin in treatment of intermittent claudication³ and of ureteral colic⁴ was formerly, and has been again recently, stressed. The scope of claims for their antispasmodic ac- tion has been extended to the relief of pain in angina . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Department of Pharmacology and Therapeutics, Stanford University School of Medicine.

Footnotes
At present, Senior Medical Officer, Drug Division, Federal Security Agency, Washington, D. C.

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