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REVIEW OF THE RECENT LITERATURE

CHARLES F. MOHR, M.D.; VIRGIL SCOTT, M.D.; RICHARD D. HAHN, M.D.; E. GURNEY CLARK, M.D.; JOSEPH EARLE MOORE, M.D.

Arch Intern Med. 1944;74(6):457-478.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

UNTOWARD EFFECTS OF TREATMENT

Arsenical Encephalopathy.

—Since the advent of more intensive methods of treating early syphilis, a steadily increasing interest is evident in arsenical encephalopathy. This has resulted in more cases being reported, as well as investigations to determine the exact nature of the lesions.

Scheinker⁶⁷ has had an opportunity to study 5 cases of encephalopathy due to arsphenamine, in all of which hemorrhages and typical vascular alterations were predominant. The vascular lesions were similar to those previously described in cases of injury to the brain and spinal cord under the heading "central vasoparalysis."

The author suggests the following theory of pathogenesis:

The main vascular alterations observed in all cases of encephalopathy caused by arsphenamine correspond to those lesions described under the heading of central vasoparalysis. These vascular lesions occur as a result of the presence of an acute physical or chemical irritant, and . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

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