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J. FREDERICK BELL, Ph.D.; OSCAR B. KAHN, M.D.

Arch Intern Med. 1945;75(3):155-158.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Rather extensive literature is accumulating on therapy for tularemia. Among the numerous agents used for the treatment of tularemia, several have received special mention. These are: (1) serum, (2) sulfonamide compounds, (3) arsenic compounds, (4) ferrous iodide, (5) metaphen and (6) acriflavine.

In brief résumé, the first of these, serum, has had the most extensive trials both clinically and experimentally. Unfortunately the work of Foshay¹ in clinical trials and of Francis and Felton² in experimental trials has led to opposing conclusions. The data which Foshay obtained from treating human beings led him to believe that serum effects a significant reduction in both morbidity and mortality. Francis and Felton, on the other hand, concluded that antitularemic serums prepared from horses, sheep and rabbits as well as from convalescent human beings show no evidence of protective effect in white mice.

Many other clinicians have reported on the use of serum . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

Alexander Blain Hospital Research Associate in Pathology, Wayne University College of Medicine, Detroit.

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