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REPORT OF A CASE AND REVIEW OF THE LITERATURE

V. ANTONIO DEL SOLAR, M.D.; G. GASTON DUSSAILLANT, M.D.; B. MOISÉS BRODSKY, M.D.; C. GUILLERMO RODRÍGUEZ, M.D.

Arch Intern Med. 1945;75(4):241-247.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During the last decade a revived interest in the treatment of arterial hypertension with thiocyanates, with varying degrees of success, has occurred. The toxic properties of these drugs have been known since the pharmacologic observations of Claude Bernard in 1857.¹ Their noxious effects have been well recognized in recent years.² The Council on Pharmacy and Chemistry of the American Medical Association has not accepted them and even has advised against their use.³ Great progress in the field was made by Barker in 1936^2f with the introduction of the practice of determining serially the blood content of thiocyanates. It was thought that with this method toxic blood levels, and therefore deleterious side effects, could be avoided. A few instances of serious and even fatal intoxication, however, have been recently reported. We have, unfortunately, had 1 such instance out of a series of 73 cases in which potassium . . . [Full Text PDF of this Article]

Author Affiliations
SANTIAGO, CHILE

From the Clínica Médica del Hospital San Francisco de Borja, Escuela de Medicina de la Universidad de Chile (Prof. A. Garretón-Silva), Santiago, Chile.

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