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MAXWELL M. WINTROBE, M.D.

Arch Intern Med. 1945;76(5):341-346.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

That nutritional deficiency is associated with cardiac dysfunction has been recognized for almost sixty years. Kakke, which means "disease of the legs," was the subject of a paper by the Japanese author Takaki in 1886.¹ To others this disorder was known as beriberi. The Hollander Eijkman² and the Englishmen Fraser and Stanton³ offered proof of the relation of beriberi to the consumption of a diet of polished rice. The elucidation of the cause of oriental beriberi is correlated with the development of knowledge concerning the vitamins.

HISTORY AND CLINICAL DESCRIPTIONS OF BERIBERI

As is well known, beriberi was prevalent in the Philippines. Chamberlain⁴ reported that among 5,000 Philippine Scouts there were always 100 to 600 incapacitated from beriberi. Their diet consisted essentially of 12 ounces (340 Gm.) of beef, 8 ounces (230 Gm.) of white flour, 8 ounces of potatoes or onions and 20 ounces (560 . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the Department of Internal Medicine of the University of Utah.

Footnotes
Presented as guest speaker, at the Fifteenth Annual Postgraduate Symposium on Heart Disease, San Francisco, Oct. 27, 1944, unde rthe auspices of the Heart Committee of the San Francisco Tuberculosis Association. The experimental studies on pigs described in this report were carried out with the aid of grants received chiefly from the Rockefeller Foundation, Parke, Davis & Company and the Upjohn Company.

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