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CAPTAIN LESTER D. ELLERBROOK; LIEUTENANT COLONEL STUART W. LIPPINCOTT; SECOND LIEUTENANT CARLO F. CATENO; MAJOR HARRY H. GORDON; COLONEL ALEXANDER MARBLE

Arch Intern Med. 1945;76(5):352-357.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The development of an adequate technic for determining plasma quinacrine concentrations¹ has facilitated the investigation of several important phases of therapy for soldiers evacuated from the South Pacific with chronic relapsing Plasmodium vivax malaria. The concentrations of quinacrine in plasma attained at selected intervals as the result of oral administration of known amounts of the drug have been determined for specific dosages. Determinations were made on 6,733 specimens from 291 patients during and after treatment for four hundred and twelve attacks of malaria at Harmon General Hospital.

METHODS

The method of Brodie and Udenfriend¹ was employed in the determination of the concentration of quinacrine in plasma. Plasma was used instead of whole blood because these investigators stated that variations in values in whole blood quinacrine concentrations are often reflections of changes in the number of leukocytes, since they contain a concentration several hundred times that of plasma. Shortly . . . [Full Text PDF of this Article]

Author Affiliations
SANITARY CORPS, ARMY OF THE UNITED STATES; MEDICAL CORPS, ARMY OF THE UNITED STATES; SANITARY CORPS, ARMY OF THE UNITED STATES; MEDICAL CORPS, ARMY OF THE UNITED STATES

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