This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (91)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JOHN D. ADCOCK, M.D.; ROBERT A. HETTIG, M.D.

Arch Intern Med. 1946;77(2):179-195.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Streptomycin, an antibiotic substance obtained from the microorganism Actinomyces griseus, was described in January 1944 by Schatz, Bugie and Waksman.¹ This material was shown to possess activity in vitro over a wide range of bacteria but was of particular interest because it was effective against many bacteria which were not susceptible to the chemotherapeutic substances then available for the treatment of human infections. Subsequent reports have confirmed these observations and, in addition, have shown that streptomycin is effective in the treatment of experimental infections with organisms of the Eberthella and Salmonella groups² and with Pseudomonas aeruginosa, Shigella gallinarum, Brucella abortus and Proteus vulgaris,³ as well as with Pasteurella tularensis⁴ and with the Klebsiella organisms.⁵ Streptomycin was also found to possess activity against the tubercle bacillus both in vitro⁶ and in vivo.⁷ The toxicity of a partially purified product for mice was reported to be of a fairly low order . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

From the Department of Internal Medicine, University Hospital, University of Michigan.

Footnotes
These studies were aided by grants from the Board of Governors of the Horace H. Rackham School of Graduate Studies and from the Executive Board of the School of Graduate Studies of the University of Michigan.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?