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Report of a Case

LIEUTENANT HOWARD W. CRAIL, MC

Arch Intern Med. 1946;78(1):14-27.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

FROM time to time cases have been reported in the literature in which there were splenomegaly and an unusual white blood cell count, which do not fit into any recognized pathologic category. Such cases are reported as: "Chronic nonleukemic myelosis"¹; "myelofibrosis associated with a leukemoid blood picture"²; "osteosclerosis with extensive extramedullary hematopoiesis and a leukemoid blood picture"³; "marrow sclerosis associated with massive myeloid splenomegaly"⁴; "splenomegaly with myeloid transformation"⁵; "megakaryocytic myelosis with osteosclerosis,"⁶ and "aleukemic myelosis with osteosclerosis."⁷ The similarity between these cases and the one reported here is striking and suggests the possibility of a disease entity which is infrequent enough to elude early recognition.

All of these cases in which there was splenomegaly have been characterized by megakaryocytes in the spleen, liver, lung, lymph nodes, peripheral blood and elsewhere with an accompanying disturbance in the number and type of circulating platelets. The circulating white blood cells, regardless of the total count, have shown myeloblastic . . . [Full Text PDF of this Article]

Author Affiliations
U.S.N.R.

From the Department of Pathology, Naval Medical School, National Naval Medical Center, Bethesda, Md.

Footnotes
This article has been released for publication by the Division of Publications of the Bureau of Medicine and Surgery of the United States Navy. The opinions and views set forth are those of the writer and are not to be construed as reflecting the policies of the Navy Department.

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