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Joint Report of the Armored Medical Research Laboratory, Fort Knox, Ky., and the Commission on Tropical Diseases, Army Epidemiological Board, Preventive Medicine Service, Office of The Surgeon General, United States Army

Arch Intern Med. 1946;78(1):64-107.

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INTRODUCTION

THIS report deals with a study¹ carried out at the Armored Medical Research Laboratory as a part of the program of the Commission on Tropical Diseases of the Surgeon General's Office for the investigation of quinacrine hydrochloride (atabrine) therapy. The primary purposes of the study were: (1) to determine the plasma quinacrine levels in large groups of healthy young men on several suppressive regimens of the drug, (2) to determine the influence of a simulated jungle climate on plasma quinacrine concentrations, (3) to determine the effect of quinacrine on acclimatization and performance of men in humid heat and (4) to determine the plasma concentrations for therapeutic levels of quinacrine intake and relate these concentrations to the plasma concentrations of the same subjects on suppressive regimens. It was anticipated that such information, together with that which was already available,² would facilitate the designing of regimens of quinacrine therapy . . . [Full Text PDF of this Article]

Footnotes
The following persons collaborated in this investigation: from the staff of the Armored Medical Research Laboratory—Major Norton Nelson and Lieutenant Colonel Frederick S. Brackett, Sanitary Corps, Army of the United States, and Major William F. Ashe, Major Ludwig W. Eichna and Major William B. Bean, Medical Corps, Army of the United States; specially attached through the Office of the Surgeon General—First Lieutenant E. D. Connor, Lieutenant Colonel A. C. McGuinness, Captain Morris Rosenfeld, Captain L. D. Rosenman and Captain Maurice Wince, Medical Corps, Army of the United States, and Captain R. G. Gould, Sanitary Corps, Army of the United States; representing the Commission on Tropical Diseases, Army Epidemiological Board—James A. Shannon, M.D.

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