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An Analysis and Discussion of Seven Cases

LIEUTENANT COLONEL J. MURRAY KINSMAN; CAPTAIN C. ANTHONY D'ALONZO; CAPTAIN SIMON RUSSI

Arch Intern Med. 1946;78(2):139-169.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

FOR HALF a century reports have been appearing in the literature describing a febrile illness which was characterized by the sudden development of a state of shock, by the prominence of hemorrhagic cutaneous rashes, by the remarkably early fatal termination and by the finding of adrenal hemorrhages post mortem. Exceptionally cutaneous eruptions were lacking, and occasionally the adrenal glands were not hemorrhagic.

Voelcker,¹ in 1894, was the first to describe this syndrome, followed by Waterhouse² in 1911 and Friderichsen³ in 1918. In time, the term "Waterhouse-Friderichsen syndrome" came to be applied to any illness of this nature, and this term has now become firmly entrenched in the literature. In none of the cases reported by those authors was the cause of the disease discovered, but in 1916 Maclagan and Cooke⁴ reported the occurrence of the syndrome in association with meningococcic meningitis.

There have been reported to . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL CORPS, ARMY OF THE UNITED STATES

From the Medical Service, Regional Station Hospital, Fort Bragg, N. C.

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