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A. DE VRIES, M.D.

Arch Intern Med. 1946;78(2):181-196.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE Saxl and Heilig¹ introduced the organic mercurial diuretics into the treatment of cardiac edema, many studies have been reported concerning their mechanism of action. The renal action of these diuretics has been proved by experiments on the isolated heart-lung-kidney preparation (Gremels²) and by observations on transplanted kidneys (Govaerts³). Investigations using the creatinine clearance method on dogs (Schmitz⁴) and on men (Herrmann and his colleague⁵) showed that the administration of these diuretics effected a diminished tubular reabsorption.

Evidence for an extrarenal action of the organic mercurial diuretics has also been brought forward, but is less convincing. The method usually employed when this problem of renal as against extrarenal action of mercurial diuretics is investigated is to examine the fluctuations in hemoglobin content or hematocrit values, total plasma protein and plasma volume during diuresis. It is reasoned that a primary extrarenal action of these drugs, effecting . . . [Full Text PDF of this Article]

Author Affiliations
JERUSALEM, PALESTINE

From the Medical Department, Division B, Rothschild Hadassah University Hospital and from the Laboratory of Pathological Physiology, Hebrew University, Jerusalem, Palestine.

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