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Report of a New Hematologic Syndrome with Observations on the Origin and Development of Megakaryocytes and on the Derivation of Platelets

VICTORINO DE LA FUENTE, M.D.

Arch Intern Med. 1946;78(4):387-404.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HITHERTO there have been only two diseases known in which he megakaryocytes occupy the center of the pathologic picture. One is thrombopenic purpura, in which these cells suffer an injury. The other is chronic aleukemic myelosis, characterized by an extramedullary megakaryopoiesis. A case of acute megakaryoblastic leukemia, the only one so far recorded in the literature, was described by von Boros.¹ However, its authenticity is doubted by some hematologists.² In other lesions in which these bone marrow cells are involved, such as in chronic myeloid leukemia, hyperthyroidism and polycythemia, they merely play a secondary role.

In the present case the megakaryocytes were the elements affected principally and in a manner unique in hematologic history. It is reported, also, because of the light it throws on the problems concerning the origin and maturation of megakaryocytes and the derivation of platelets from them.

REPORT OF A CASE

G. M., a . . . [Full Text PDF of this Article]

Author Affiliations
MANILA, PHILIPPINE ISLANDS

From the San Juan de Dios Hospital, the Department of Internal Medicine, University of Santo Tomas and Clinica Singian, Manila, Philippine Islands.

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