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Further Studies; Investigation of Chemical Changes in Myocardial Insufficiency with Special Reference to Adenosinetriphosphate

GEORGE H. MANGUN, Ph.D.; VICTOR C. MYERS, Ph.D., D.Sc.

Arch Intern Med. 1946;78(4):441-446.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING the past decade chemical studies have been made on the human heart by workers from several laboratories in an effort to correlate heart failure with known facts of muscle chemistry. From these studies has come a consistent agreement among all published data that creatine is usually decreased in the failing heart. Total phosphorus and acid-soluble phosphorus have likewise been found to be decreased,¹ and most workers have found a lowered potassium. To investigate further the chemical changes associated with myocardial insufficiency, Mangun and Roberts² studied acid-soluble phosphorus compounds of the dog's heart in aortic insufficiency. No losses were observed in the early stages, but in 2 dogs allowed to progress into the late stages of cardiac failure (approximately one year later) a marked decrease was noted in the adenosinetriphosphate and phosphocreatine content of the left ventricle. These findings made it desirable to investigate . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO; CLEVELAND

From the Department of Biochemistry, School of Medicine, Western Reserve University. The material for this study was obtained through the cooperation of the Department of Pathology, Western Reserve University.

Footnotes
Aided by a grant from the Josiah Macy Jr. Foundation.

A preliminary report of this work was presented before the American Society of Biological Chemists, 1940. Mangun, G. H., and Myers V. C.: Purine Content of Human Cardiac and Voluntary Muscle, J. Biol. Chem. 133: lxii, 1940.

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