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A Review of the Recent Literature

FRANK W. REYNOLDS, M.D.; JOSEPH EARLE MOORE, M.D.

Arch Intern Med. 1947;79(1):92-112.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

STREPTOMYCIN IN SYPHILIS

Herrell and Nichols¹⁹⁶ have treated 4 patients with syphilis with 10,000,000 units of streptomycin given in divided doses over a period of ten days. In 3 cases of early syphilis results were negative at dark field examination after treatment, but in each case clinical relapse was observed. One patient with late gummatous syphilis had "temporary improvement."

Dunham and Rake¹⁹⁷ infected rabbits by the intracutaneous injection of T. pallidum and three days later gave to alternate animals intramuscular injections of streptomycin or crystalline penicillin G. The small amount of streptomycin that cured any of the rabbits when administered in divided doses over a four day period was 79,000 units per kilogram (375 mg. per kilogram) in one experiment and 187,000 units per kilogram (817 mg. per kilogram) in another. Since a comparable effect was obtained with 147 units per kilogram (0.088 mg. . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

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