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SEPTIC STAPHYLOCOCCEMIA SUCCESSFULLY TREATED BY PENICILLIN AND BACTERIOPHAGE
WARD J. MacNEAL, M.D.;
ANNE BLEVINS, R.N.;
ROBERT McGRATH, M.D.
Arch Intern Med. 1947;79(4):391-400.
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SEPTIC staphylococcemia, its complications and sequelae have been a major problem for study by our group for many years. Several papers have appeared from time to time dealing with the use of bacteriophages in many hundreds of patients and presenting in detail the therapeutic program in some of the more serious clinical varieties of this infection, such as osteomyelitis, septic thrombosis of the cavernous sinus, staphylococcic meningitis and staphylococcic endocarditis. The introduction of the sulfonamide drugs and subsequently of penicillin was followed by their enthusiastic use against staphylococcic infections, with success in many instances. More recently, streptomycin is being employed against the staphylococcus because of the well known but inadequately discussed failures in sulfonamide and penicillin therapy of infections with resistant staphylococci. At this time we wish to present the record of a patient with fulminant septic staphylococcemia, apparently complicated by localization on the endocardium and in the lumbar portion
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Department of Bacteriology and the Department of Medicine, New York Post-Graduate Medical School and Hospital, Columbia University.
Footnotes
Aided by grant no. 539 of the Committee on Therapeutic Research, Council on Pharmacy and Chemistry, American Medical Association.
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