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A Comparison of Acute Cardiac Toxicity in Animals and the Effect of Ascorbic Acid on Detoxification in Their Intravenous Administration

DON W. CHAPMAN, M.D.; CARL F. SHAFFER, M.D.

Arch Intern Med. 1947;79(4):449-456.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ACUTE toxicity of mercurial diuretics has been noted frequently, but no extensive investigation of substances to counteract this toxicity has been reported.¹ There are two apparently distinct immediate reactions in human beings—a nonfatal hypersensitivity² and a fatal cardiac reaction. Experiments in animals^1a and observations in human beings^1c have determined that death is caused by ventricular fibrillation.

Ascorbic acid has been used to detoxify chemotherapeutic heavy metals, especially arsenic.³ It is an effective physiologic reducing agent. Certain animals, including dogs, can synthesize ascorbic acid and are therefore suitable experimental animals.

We have extended the investigation of the mechanism of immediate death in dogs from mercurial diuretics for the three commonly employed ones, mercurophylline injection, mersalyl and theophylline and mercuhydrin. We have also studied the possible detoxifying effect of ascorbic acid on these preparations. The addition of another substance to a mercurial diuretic in an effort to . . . [Full Text PDF of this Article]

Author Affiliations
HOUSTON, TEXAS

From the Department of Medicine, Baylor University College of Medicine, and Hermann Hospital.

Footnotes
Read before the Central Society for Clinical Research, Chicago, Nov. 1, 1946

This research was aided in part by a grant from the M. D. Anderson Foundation.

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