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EXPERIMENTALLY INDUCED INFECTIOUS HEPATITISRoentgenographic and Gastroscopic Observations
W. PAUL HAVENS, Jr., M.D.;
SAMUEL D. KUSHLAN, M.D.;
M. RAGAN GREEN, M.D.
Arch Intern Med. 1947;79(4):457-464.
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THE OCCURRENCE of anorexia, nausea, vomiting and abdominal pain during the preicteric and early icteric phases of infectious hepatitis has suggested that involvement of the gastrointestinal tract may be an important feature of this disease. The fact that the etiologic agent of infectious hepatitis is eliminated in the stools of patients in the acute phase of the disease and may be transmitted experimentally by feeding such material to human volunteers adds supporting evidence to this concept.1 More objective criteria have been afforded by the demonstration at autopsy of regional lymphadenopathy as well as edema and phlegmonous changes in the stomach and small and large bowel in fatal cases.2 In an effort to demonstrate changes in the gastrointestinal tract during infectious hepatitis, certain roentgenologic and gastroscopic studies have been made. Pöschl3 has reported alteration in the antral portion of the stomach and first part of the duodenum,
. . . [Full Text PDF of this Article]
Author Affiliations
NEW HAVEN, CONN.
From the Section of Preventive Medicine, the Department of Medicine and the Department of Radiology, Yale University School of Medicine.
Footnotes
Acknowledgment is made of the assistance and cooperation of the following agencies: Selective Service, Camp Operations Division; Civilian Public Service Unit No. 68; Civilian Public Service Unit No. 140, and the Connecticut State Hospital, Middletown, Conn.
These investigations were aided in part by the Neurotropic Virus Disease Commission of the Board for the Investigation and Control of Influenza and Other Epidemic Diseases in the Army, in the Preventive Medicine Service of the Office of The Surgeon General, United States Army, Washington, D. C.
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